Игорь Иванович
Тор4People
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- 3 Апр 2023
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Цитата из забугорной научной литературы
One reason for the development of receptor-specific drugs is to create substances that have higher safety margins, higher differences between the median lethal dose and the median effective dose. Classically, anesthesiologists have used drugs that have low therapeutic indices, which simply means that the lethal and/or dangerous dose or concentration is close to the effective analgesic or anesthetic dose. Pentothal and meperidine are examples of drugs with low therapeutic indices. But some of the new ones—for example, fentanyl, sufentanil, alfentanil, and ketamine—have therapeutic indices that are measured in the hundreds or thousands. Of the available opioids, fentanyl has a higher therapeutic index than morphine (400 vs 70), and remifentanil has the highest therapeutic index of any opioid or anesthetic (33,000).
One reason for the development of receptor-specific drugs is to create substances that have higher safety margins, higher differences between the median lethal dose and the median effective dose. Classically, anesthesiologists have used drugs that have low therapeutic indices, which simply means that the lethal and/or dangerous dose or concentration is close to the effective analgesic or anesthetic dose. Pentothal and meperidine are examples of drugs with low therapeutic indices. But some of the new ones—for example, fentanyl, sufentanil, alfentanil, and ketamine—have therapeutic indices that are measured in the hundreds or thousands. Of the available opioids, fentanyl has a higher therapeutic index than morphine (400 vs 70), and remifentanil has the highest therapeutic index of any opioid or anesthetic (33,000).