Забыл добавить,что из укропа,по ходу,сабж не получить.Из него можно получить ДММДА-2.
#59 DMMDA-2; 2,3-DIMETHOXY-4,5-METHYLENEDIOXYAMPHETAMINE
DOSAGE: about 50 mg.
DURATION: unknown.
QUALITATIVE COMMENTS: (with 50 mg) I am into it; it is much like
MDA.
EXTENSIONS AND COMMENTARY: This is pretty sparse information upon
which to build a picture of biological activity. First, the synthesis
was done by someone else and, as I have not been able to find where
the notes are, this will be the one recipe in the footnote without
explicit directions incorporated. The procedure used was exactly the
same as that described for DMMDA, except that the starting material
was dillapiole rather than apiole. The dillapiole was obtained by the
careful fractionation of Oil of Dill (as opposed to the isolation of
apiole from the careful fractionation of Oil of Parsley).
Isomerization to isodillapiole, nitration with tetra-nitromethane to
give 1-(2,3-dimethoxy-4,5-methylenedioxyphenyl)-2-nitropropene, and
its reduction with LAH in ether to give
2,3-dimethoxy-4,5-methylenedioxyamphetamine hydrochloride (DMMDA-2)
proceeded in a precisely analogous manner to the preparation of DMMDA.
And the pharmacological part is rather thin as well. I was not the
taster, and can only quote what I had been given. This same observer
found a threshold at 28 milligrams. Under other circumstances, this
comment on DMMDA-2 would have been tucked into the commentary on DMMDA
where it belongs, but the activity level was called for in a large
review article, and on the basis of the above, both its initials and
the value of 5x the potency of mescaline were permanently enshrined in
the published literature. What is it really like? I don't know. Its
structure is an appealing amalgamation of that of MMDA and MMDA-2, and
it might be quite a winner if the dosage and the duration were known.
It is, after all, one of the ten essential amphetamines, since
dillapiole is one of the ten essential oils.
At the time that DMMDA and DMMDA-2 were synthesized, I had visions of
doing the same thorough study with these as I had set up with the
TMA's (six possible, six done) and the MMDA's (six possible, five
done). Here, too, with a pair of methoxy groups on an amphetamine
skeleton, with a methylenedioxy ring thrown in, six isomers are
possible but only these two have been prepared. The unknown ones will
certainly be called DMMDA-3, -4, -5 and -6, but the assignments of
code to structure haven't even been thought out yet. The remarkable
and totally unexpected activity of DOM was discovered at about this
time and it was a much more tempting direction to follow. The
remaining four possible DMMDA's have been left to that famous time, a
future Rrainy day.
