Вы наверняка слышали или читали слухи о том, что якобы новый коронавирус — это биологическое оружие.
Лично мне не кажется, что это "слухи". В сущности, первая эпидемия SARS 2002-3 годов произошла достаточно далеко от Ухани. С чего бы вдруг вторая, будь она естественной, переместилась так далеко как от первоначального очага, так и от областей, где живут циветты или летучие мыши-переносчики подходящих вирусов? Также я помню большой шум в 2015 году, когда проводили работы с вирусом SARS, с целью доказать, что он может передаваться от человека к человеку. Собственно, работа в том и заключалась - вирус изменяли и усиливали, и доказали экспериментально, что его производные передаются от человека к человеку и способны вызывать эпидемии.
Приведённая статья очень интересна. Многое говорит за то, что виновницей всего является уханьская лаборатория. Я тоже нашла довольно неплохую статью на эту тему, которую долго собиралась, и наконец-то перевела.
В известной мере она дублирует приведённую выше статью, но и дополняет её. И, на мой взгляд, довольно любопытной её частью являются ссылки на использованные публикации.
В общем, я приведу её здесь и в оригинале (прямую ссылку я потеряла, остался только текст) и в переводе двумя постами подряд, за что заранее прошу прощения. Но так, мне кажется, будет удобнее. И если модеры решат, что оригинал текста не нужен, его можно будет ликвидировать.
The 2019-nCoV has caused an epidemic of 28,060 laboratory-confirmed infections in human including 564 deaths in China by February 6, 2020. Two descriptions of the virus published on Nature this week indicated that the genome sequences from patients were almost identical to the Bat CoV ZC45 coronavirus. It was critical to study where the pathogen came from and how it passed onto human. An article published on The Lancet reported that 27 of 41 infected patients were found to have contact with the Huanan Seafood Market in Wuhan. We noted two laboratories conducting research on bat coronavirus in Wuhan, one of which was only 280 meters from the seafood market. We briefly examined the histories of the laboratories and proposed that the coronavirus probably originated from a laboratory. Our proposal provided an alternative origin of the coronavirus in addition to natural recombination and intermediate host.
The possible origins of 2019-nCoV coronavirus
Botao Xiao1,2* and Lei Xiao3
1 Joint International Research Laboratory of Synthetic Biology and Medicine, School
of Biology and Biological Engineering, South China University of Technology,
Guangzhou 510006, China
2 School of Physics, Huazhong University of Science and Technology, Wuhan
430074, China
3 Tian You Hospital, Wuhan University of Science and Technology, Wuhan 430064,
China
* Corresponding author:
[email protected]
Tel / Fax: 86-20-3938-0631
The 2019-nCoV coronavirus has caused an epidemic of 28,060 laboratory-confirmed
infections in human including 564 deaths in China by February 6, 2020. Two descriptions
of the virus published on Nature this week indicated that the genome sequences from
patients were 96% or 89% identical to the Bat CoV ZC45 coronavirus originally found in
Rhinolophus affinis 1,2. It was critical to study where the pathogen came from and how it
passed onto human.
An article published on The Lancet reported that 41 people in Wuhan were found to
have the acute respiratory syndrome and 27 of them had contact with Huanan Seafood
Market 3. The 2019-nCoV was found in 33 out of 585 samples collected in the market after
the outbreak. The market was suspicious to be the origin of the epidemic, and was shut
down according to the rule of quarantine the source during an epidemic.
The bats carrying CoV ZC45 were originally found in Yunnan or Zhejiang province,
both of which were more than 900 kilometers away from the seafood market. Bats were
normally found to live in caves and trees. But the seafood market is in a densely-populated
district of Wuhan, a metropolitan of ~15 million people. The probability was very low for the
bats to fly to the market. According to municipal reports and the testimonies of 31 residents
and 28 visitors, the bat was never a food source in the city, and no bat was traded in the
market. There was possible natural recombination or intermediate host of the coronavirus,
yet little proof has been reported.
Was there any other possible pathway? We screened the area around the seafood
market and identified two laboratories conducting research on bat coronavirus. Within ~280
meters from the market, there was the Wuhan Center for Disease Control & Prevention
(WHCDC) (Figure 1, from Baidu and Google maps). WHCDC hosted animals in laboratories
for research purpose, one of which was specialized in pathogens collection and identification 4-
6. In one of their studies, 155 bats including Rhinolophus affinis were captured in Hubei
province, and other 450 bats were captured in Zhejiang province 4.
Expert knew the extreme danger of the infection so he quarantined himself for 14 days 7. In another accident,
he quarantined himself again because bats peed on him. He was once thrilled for capturing
a bat carrying a live tick 8.
Surgery was performed on the caged animals and the tissue samples were collected for
DNA and RNA extraction and sequencing 4, 5. The tissue samples and contaminated trashes
were source of pathogens. They were only ~280 meters from the seafood market. The
WHCDC was also adjacent to the Union Hospital (Figure 1, bottom) where the first group
of doctors were infected during this epidemic. It is plausible that the virus leaked around
and some of them contaminated the initial patients in this epidemic, though solid proofs
are needed in future study.
The second laboratory was ~12 kilometers from the seafood market and belonged to
Wuhan Institute of Virology, Chinese Academy of Sciences 1, 9, 10. This laboratory
reported that the Chinese horseshoe bats were natural reservoirs for the severe acute
respiratory syndrome coronavirus (SARS-CoV) which caused the 2002-3 pandemic 9.
The principle investigator participated in a project which generated a chimeric virus using
the SARS-CoV reverse genetics system, and reported the potential for human
emergence 10. A direct speculation was that SARS-CoV or its derivative might leak from
the laboratory.
In summary, somebody was entangled with the evolution of 2019-nCoV coronavirus.
In addition to origins of natural recombination and intermediate host, the killer coronavirus
probably originated from a laboratory in Wuhan. Safety level may need to be reinforced in
high risk biohazardous laboratories. Regulations may be taken to relocate these
laboratories far away from city center and other densely populated places.
Contributors
BX designed the comment and performed literature search. All authors performed data
acquisition and analysis, collected documents, draw the figure, and wrote the papers.
Acknowledgements
This work is supported by the National Natural Science Foundation of China (11772133,
11372116).
Declaration of interests
All authors declare no competing interests.
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